A Miniaturized Drug-delivery System for Intra-corporeal Use
نویسنده
چکیده
In this paper we present a novel drug delivery device that: 1. is able to release drug in a controllable way (one shot, multiple shots, continuous release); 2. has power requirements compatible with those of standard integrated circuits; 3. can be easily miniaturized. The actuation principle relies on the electrolysis of a waterbased solution that is kept separated from the drug by an elastic membrane. The pressure generated inside the chamber containing the electrolytic solution causes an outward deflection of the membrane that forces the drug to exit its storing chamber through an outlet orifice. The drug out-flow can be electronically controlled and different releasing modes can be achieved (one shot, multiple shots, continuous delivery). Voltages as low as 2V are able to activate the device, with extremely small currents ( 1mA). A first prototype has been fabricated and tested. Flowrate and pressure vs. time measurements have been performed, which confirm the suitability of the device for in-body applications.
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